Trisagion is an unlockable passive item in The Binding of Isaac, added in the Afterbirth+ DLC.

Replaces Isaac's tears with piercing white beams of light that deal 33% of Isaac's damage, but can hit the same enemy multiple times.

Beams decrease in size until disappearing.

Lower shot speed is more beneficial as it can cause enemies to get hit more times.

Beams can hit enemies through obstacles, but only when passing through only 1 obstacle.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Take 25 Angel Room items.

Trisagion can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Trisagion have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Trisagion

• Replaces tears with large piercing bursts of holy energy
• The bursts deal reduced damage but can damage enemies multiple times as they pass through
• Abyss: x1 holy locust 1.5x Isaac's damage

• Check out the item description on the external Isaac Wiki.