Ice Cube is an unlockable trinket in The Binding of Isaac, added in the Repentance DLC.

Upon entering a room, each enemy has a 20% chance to be petrified, and freeze when killed.

Petrification lasts for 4 seconds, and enemies can be frozen up to 2 more seconds after the petrificaton effect.

The chance for enemies to be petrified scales with luck, reaching 100% at 40 luck.

The freezing effect is the same one granted by Uranus. Check the item page for more details about ice statues.

Bosses can get petrified, but won't get frozen.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this trinket for the previous Repentance version, check this page instead.

Complete challenge #41: Pica Run.

Ice Cube can be found in the following item pools:

The following tags are applied to this trinket:

The following special synergies and interactions for Ice Cube have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Ice Cube

• 20% chance for enemies to be petrified when entering a room
• Golden Trinket (without Mom's Box): 33% chance for enemies to be petrified when entering a room
• Mom's Box: 33% chance for enemies to be petrified when entering a room
• Mom's Box + Golden Trinket: 50% chance for enemies to be petrified when entering a room
• Killing a petrified enemy freezes them
• Chance increases with luck

• Check out the trinket description on the external Isaac Wiki.