Magic Skin is an unlockable active item in The Binding of Isaac, added in the Repentance DLC.

On use -1 Heart Container, Bone Heart or 2 Soul Hearts (chosen by priority as shown).
+1 Broken Heart which can never be filled, permanently reducing Isaac's maximum possible health.

Spawns an item from the current room's item pool.

Disappears after being used 12 times (or 18 times if playing as Magdalene with Birthright).

The Lost and Tainted Lost can only use the item once before it disappears.

While heldAfter using Magic Skin, if Isaac drops the item, any item that spawns in the future will have a chance to be replaced by Magic Skin.

The chance for this to happen is 33% after the first use, 50% after 2 uses, and 100% after 3 uses. This chance is drastically reduced if Magic Skin is on a pedestal somewhere on the current floor.

This page shows information as of the latest Repentance release.
To see latest up-to date information about this item for the new Repentance+ (Online Co-op) DLC, check this page instead.

Defeat Mother as Jacob and Esau.

Magic Skin can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Magic Skin have been documented.

* Note that not all possible synergies and interactions are listed here.

• Check out the item description on the external Isaac Wiki.