Devolution Serum is a passive item in Ephemera, a mod for The Binding of Isaac.

Adds a chance to fire a reroll tear that devolves the hit monster into a weaker variant of themself.

Each type of monster has a specific devolve path it takes.

If a monster is at its weakest level, it will mostly transform into a background critter or simply die.

Some enemies can be transformed into obstacles or pickups.

The chance to fire a reroll tear starts at 5% with 0 luck and maximizes at 50% with 18 luck.

Devolution Serum can be found in the following item pools:

• Download Ephemera from the Steam Workshop.