Mom's Chest - The Binding of Isaac

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Mom's Chest is a pickup in The Binding of Isaac, added in the Repentance DLC.

Does not have a requirement to open.

Cannot be duplicated with any item.

Contains Red Key when opened for the first time, or an item from the Mom's Chest item pool otherwise.

Spawns in Mom's room in the Home level.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this pickup for the previous Repentance version, check this page instead.