Angry Fly is an unlockable familiar in The Binding of Isaac, added in the Afterbirth+ DLC.

Spawns a fly familiar that orbits around a random enemy in the room, dealing 2 damage per tick (30 per second) to enemies coming into contact with it.

The familiar occasionally makes a lunge towards the enemy it is orbiting, allowing brief contact even with smaller enemies.

When the enemy it was orbiting dies, it starts orbiting a different enemy.

When there are no enemies in the room, it will instead orbit Isaac.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Transform into Beelzebub.

This item contributes towards the Beelzebub transformation. Collecting 3 items from this set will grant Isaac flight, converts small enemy flies into Blue Flies, and permanently charms larger enemy flies.

Angry Fly can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Angry Fly have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Angry Fly

• Fly familiar that orbits a random enemy, dealing contact damage to other enemies
• Orbits Isaac only when no enemies are present
• Abyss: x1 homing locust .75x Isaac's damage

• Check out the item description on the external Isaac Wiki.