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Mr. ME! item
Mr. ME! is an unlockable active item in The Binding of Isaac, added in the Afterbirth+ DLC.
Description
Summons a ghost that follows Isaac and a controllable blue crosshair on the ground. The crosshair disappears after a few seconds, and the ghost will act based on what the crosshair's was targeting:
• Item / Pickup / Trinket / Chest / Red Chest / Spiked Chest / Mega Chest: brings it to Isaac.
• Shop or Devil Deal Item/Pickup: has a 50/50 chance to either grab the item for free or fail, making the ghost disappear and do nothing.
• Locked Chest / Eternal Chest / Bomb Chest: opens it for free.
• Button/Reward Plate: presses the button.
• Enemy: attacks it until it dies or can no longer be targeted due to a form change or similar cause. Deals 3 damage per tick (9 per second).
• Door: opens the door, even if locked. Can open the door to Mega Satan, Hush (only exit) and Boss Rush (only exit).
• Secret Room entrance: blows up and opens the entrance.
• Destructible obstacle / Shopkeeper / Machine / Beggar: explodes and destroys it.
• Nothing: interacts with the object closest to Isaac.
Note
This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.
How to unlock?
Open 20 Locked Chests.
Item pools
Mr. ME! can be found in the following item pools:
| Name | Weight |
|---|---|
| Shop |
1.0/1.0
|
| Key Master |
1.0/1.0
|
| Greed Shop |
1.0/1.0
|
| Crane Game |
1.0/1.0
|
| Wooden Chest |
1.0/1.0
|
Tags
The following tags are applied to this item:
| Id | Description |
|---|---|
| offensive | Can appear for  Tainted Lost. |
Special synergies
The following special synergies and interactions for Mr. ME! have been documented.
| Mod | Item | Synergy |
|---|---|---|
| --- | Book of Virtues | Spawns a face-like wisp in the middle ring. The wisp cannot shoot. Once the room is cleared, the wisp will unlock the nearest Locked Chest or special room door, destroying itself in the process. |
* Note that not all possible synergies and interactions are listed here.
Internal item description
Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.
Mr. ME!
• Spawns a blue crosshair that summons a ghost that may do helpful things depending on what is targeted
• The ghost can attack enemies, fetch items, press buttons, open most doors, and sometimes steal shop or Devil Deal items
• Abyss: x1 locust 1.5x Isaac's damage
• Book of Virtues: x1 middle wisp - 2 hp - doesn't shoot
• Book of Virtues: Wisps will unlock chests and open doors after room clear
External links
- Check out the item description on the external Isaac Wiki.
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Leprosy 
7 Seals 
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Death's List