Mr. ME! is an unlockable active item in The Binding of Isaac, added in the Afterbirth+ DLC.

Summons a ghost that follows Isaac and a controllable blue crosshair on the ground. The crosshair disappears after a few seconds, and the ghost will act based on what the crosshair's was targeting:

• Item / Pickup / Trinket / Chest / Red Chest / Spiked Chest / Mega Chest: brings it to Isaac.

• Shop or Devil Deal Item/Pickup: has a 50/50 chance to either grab the item for free or fail, making the ghost disappear and do nothing.

• Locked Chest / Eternal Chest / Bomb Chest: opens it for free.

• Button/Reward Plate: presses the button.

• Enemy: attacks it until it dies or can no longer be targeted due to a form change or similar cause. Deals 3 damage per tick (9 per second).

• Door: opens the door, even if locked. Can open the door to Mega Satan, Hush (only exit) and Boss Rush (only exit).

• Secret Room entrance: blows up and opens the entrance.

• Destructible obstacle / Shopkeeper / Machine / Beggar: explodes and destroys it.

• Nothing: interacts with the object closest to Isaac.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Open 20 Locked Chests.

Mr. ME! can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Mr. ME! have been documented.

* Note that not all possible synergies and interactions are listed here.

• Check out the item description on the external Isaac Wiki.