Curse of the Maze! is a curse in The Binding of Isaac.
Entering a new room has a chance to take Isaac to the wrong room, indicated by a subtle screen-shake and sound effect. This can also happen when teleporting between rooms.
Discovered rooms can randomly swap contents with another room of the same size.
This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this curse for the previous Repentance version, check this page instead.