Locust of Famine is an unlockable trinket in The Binding of Isaac, added in the Afterbirth+ DLC.

Upon entering an unexplored room, spawns a Grey Locust that dies upon impact with enemies, dealing 2x Isaac's damage for the impact, and slows the enemy.

Has a 1% chance of being dropped upon defeating Famine.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this trinket for the previous Repentance version, check this page instead.

Defeat ??? as Apollyon.

The following special synergies and interactions for Locust of Famine have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Locust of Famine

• Spawns a slowing locust upon entering a new combat room
• Golden Trinket (without Mom's Box): Spawns 2 slowing locusts upon entering a new combat room
• Mom's Box: Spawns 2 slowing locusts upon entering a new combat room
• Mom's Box + Golden Trinket: Spawns 3 slowing locusts upon entering a new combat room

• Check out the trinket description on the external Isaac Wiki.