Box of Spiders is an active item in The Binding of Isaac.

Spawns 4-8 friendly Blue Spiders.

This page shows information as of the latest Repentance release.
To see latest up-to date information about this item for the new Repentance+ (Online Co-op) DLC, check this page instead.

This item contributes towards the Spider Baby transformation. Collecting 3 items from this set will spawn a spider familiar that applies random status effects when it comes in contact with enemies.

Box of Spiders can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Box of Spiders have been documented.

* Note that not all possible synergies and interactions are listed here.

• Check out the item description on the external Isaac Wiki.