Box of Spiders is an active item in The Binding of Isaac.

Spawns 4-8 friendly Blue Spiders.

Has a 1% chance of being dropped upon defeating Rag Man.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

This item contributes towards the Spider Baby transformation. Collecting 3 items from this set will spawn a spider familiar that applies random status effects when it comes in contact with enemies.

Box of Spiders can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Box of Spiders have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Box of Spiders

• Spawns 4-8 blue spiders
• Abyss: x1 locust .75x Isaac's damage
• Book of Virtues: x1 middle wisp - 1 hp - 2 damage
• Book of Virtues: Item spawns wisps instead of spiders
• Book of Virtues: Spawns a blue spider on death

• Check out the item description on the external Isaac Wiki.