Serpent's Kiss is an unlockable passive item in The Binding of Isaac, added in the Afterbirth DLC.

Grants a 15% chance to fire poison tears that deal a total of 2x Isaac's damage.

Inflicts poison on enemies that make contact with Isaac. The poison will tick 6 times, each tick dealing Isaac's amount of damage.

Enemies that were inflicted with poison via contact damage have a 20% chance to drop a Black Heart.

This page shows information as of the latest Repentance release.
To see latest up-to date information about this item for the new Repentance+ (Online Co-op) DLC, check this page instead.

Defeat Satan as Lilith.

Serpent's Kiss can be found in the following item pools:

The following tags are applied to this item:

• Check out the item description on the external Isaac Wiki.