Glyph of Balance is an unlockable passive item in The Binding of Isaac, added in the Afterbirth+ DLC.

+2 Soul Hearts.

Modifies drops from room clears and champion enemies depending on Isaac's held amount of pickups. It prioritizes drops as follows:
• Soul Hearts: when Isaac has no red heart containers and less than 2 soul hearts.
• Full Red Hearts: when Isaac is at half a red heart.
• Keys: when Isaac has no keys.
• Bombs: when Isaac has no bombs.
• Pennies: when Isaac has less than 15 pennies.
• Keys: when Isaac has less than 5 keys.
• Bombs: when Isaac has less than 5 bombs.
• Trinkets: when Isaac has no trinkets, and there are no trinkets on the ground in the room.
• Soul Hearts: when Isaac has less than 6 total heart containers of any kind.
• If none of the above criteria are met, pickups are dropped normally.

Cannot reroll chests.

Glyph of Balance drops can appear if the room would normally yield no reward. An exception to this rule are hearts drops in Hard Mode which have a separate chance of being replaced with an empty drop.

When playing as a character that cannot have red heart containers, red heart and soul heart drops are skipped from the above list.

Having a higher luck stat means that the effects of the Glyph will occur much less frequently, as room drops will often be replaced with chests that are immune to the Glyph.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Defeat Ultra Greedier as Magdalene.

Glyph of Balance can be found in the following item pools:

The following tags are applied to this item:

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Glyph of Balance

• Alters pickup drops from room clears and champion enemies to prioritize those most lacking
• Abyss: x1 locust 1x Isaac's damage

• Check out the item description on the external Isaac Wiki.