Black Rune is an unlockable consumable in The Binding of Isaac, added in the Afterbirth+ DLC.

Activates the effects of The Necronomicon, dealing 40 damage to all enemies in the room.

Converts all pickups in the room into Blue Flies and Blue Spiders.

Converts all item pedestals in the room into random stat upgrades, similarly to consuming a passive item with Void. Will also consume active items but turn them into stats as well.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this consumable for the previous Repentance version, check this page instead.

Defeat Ultra Greedier as Apollyon.

The following special synergies and interactions for Black Rune have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Black Rune

• Deals 40 damage to enemies in the room
• Transforms pickups into blue flies and spiders
• Consumes all item pedestals and grants a random stat bonus for each
• Clear Rune: Recharge 4

The following sounds are related to this consumable.

• Check out the consumable description on the external Isaac Wiki.