Black Rune is an unlockable consumable in The Binding of Isaac, added in the Afterbirth+ DLC.
Activates the effects of The Necronomicon, dealing 40 damage to all enemies in the room.
Converts all pickups in the room into Blue Flies and Blue Spiders.
Converts all item pedestals in the room into random stat upgrades, similarly to consuming a passive item with Void. Will also consume active items but turn them into stats as well.
This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this consumable for the previous Repentance version, check this page instead.
Defeat Ultra Greedier as Apollyon.
The following special synergies and interactions for Black Rune have been documented.
Mod | Item | Synergy |
---|---|---|
--- | Clear Rune | Mimic recharge time: 4 rooms |
* Note that not all possible synergies and interactions are listed here.
The following sounds are related to this consumable.