Soul of Isaac is an unlockable consumable in The Binding of Isaac, added in the Repentance DLC.

Causes all item pedestals in the current room to cycle between the original item and an additional one.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this consumable for the previous Repentance version, check this page instead.

Defeat Hush and complete Boss Rush as Tainted Isaac.

The following special synergies and interactions for Soul of Isaac have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Soul of Isaac

• Makes item pedestals in the room cycle between a rerolled option and the original item
• Clear Rune: Recharge 4

The following sounds are related to this consumable.

• Check out the consumable description on the external Isaac Wiki.