Smart Fly is a familiar in The Binding of Isaac.

Spawns a fly familiar that orbits Isaac, blocks projectiles and deals 1.5 damage per tick (6.43 per second).

Upon taking damage in the room, the fly will seek out nearby enemies and attack them, losing the ability to block projectiles.

This page shows information as of the latest Repentance release.
To see latest up-to date information about this item for the new Repentance+ (Online Co-op) DLC, check this page instead.

This item contributes towards the Beelzebub transformation. Collecting 3 items from this set will grant Isaac flight, converts small enemy flies into Blue Flies, and permanently charms larger enemy flies.

Smart Fly can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Smart Fly have been documented.

* Note that not all possible synergies and interactions are listed here.

• Check out the item description on the external Isaac Wiki.