Depression is a familiar in The Binding of Isaac, added in the Afterbirth+ DLC.

Spawns a cloud familiar that follows Isaac and leaves a trail of damaging blue creep on the ground.

The creep deals 2 damage per tick (20 per second).

Upon touching an enemy, the cloud has a small chance to shoot a damaging Holy Light beam onto the enemy that deals 20 + DamageStat damage per tick and can strike up to 8 times.

This page shows information as of the latest Repentance release.
To see latest up-to date information about this item for the new Repentance+ (Online Co-op) DLC, check this page instead.

Depression can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Depression have been documented.

* Note that not all possible synergies and interactions are listed here.

• Check out the item description on the external Isaac Wiki.