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Depression item
Depression is a familiar in The Binding of Isaac, added in the Afterbirth+ DLC.
Description
Spawns a cloud familiar that follows Isaac and leaves a trail of damaging blue creep on the ground.
The creep deals 2 damage per tick (20 per second).
Upon touching an enemy, the cloud has a small chance to shoot a damaging Holy Light beam onto the enemy that deals 20 + DamageStat damage per tick and can strike up to 8 times.
Has a 1% chance of being dropped upon defeating Rainmaker.
Note
This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.
Item pools
Depression can be found in the following item pools:
| Name | Weight |
|---|---|
| Treasure Room |
1.0/1.0
|
| Greed Treasure Room |
1.0/1.0
|
Tags
The following tags are applied to this item:
| Id | Description |
|---|---|
| summonable | Can be summoned via  Lemegeton. |
| offensive | Can appear for  Tainted Lost. |
Special synergies
The following special synergies and interactions for Depression have been documented.
| Mod | Item | Synergy |
|---|---|---|
| --- | BFFS! | Only increases the cloud's size with no effect on damage. |
* Note that not all possible synergies and interactions are listed here.
External links
- Check out the item description on the external Isaac Wiki.
Contagion 
Finger! 
Shade 
Hushy 
Lil Monstro 
King Baby