Holy Hand Grenade is an unlockable active item in Martha of Bethany, a mod for The Binding of Isaac.

Isaac raises the Holy Hand Grenade above his head with a timer counting up.

Pressing a fire button throws the grenade, which explodes a few seconds after landing, dealing 185 damage, and synergizes with Isaac's bomb effects.

Depending on the number of the timer when Isaac throws the grenade, its explosion gains different effects:
• 2,4: The explosion leaves a large Godhead aura that lasts 7 seconds, dealing 1 damage per tick (30 per second).
• 3: Fires up to 7 light beams towards enemies in the room, each laser dealing 7 + CurrentFloor damage per tick, 15 times per second.
• 8+: Fizzles - the grenade will not explode and can be picked up and thrown at enemies again. The thrown grenade deals x2 Isaac's damage.

Throwing can be canceled by hitting the active item button again before the counter reaches 4.

The grenade may be thrown over obstacles only when fizzled out and picked up from the ground.

Defeat Satan as Martha.

Holy Hand Grenade can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Holy Hand Grenade have been documented.

* Note that not all possible synergies and interactions are listed here.

• Download Martha of Bethany from the Steam Workshop.