Pica Run is an unlockable challenge in The Binding of Isaac, added in the Repentance DLC.
This page shows information as of the latest Repentance release.
To see latest up-to date information about this challenge for the new Repentance+ (Online Co-op) DLC, check this page instead.
Note: this list does not include characters' default starting items.
All items are replaced with trinkets.
Marbles activates on every hit.
The following is unlocked for completing the Pica Run challenge: Ice Cube
Defeat Mom's Heart 11 times and unlock Marbles.