Challenges
Base game
- Isaac (Repentance+)
- Isaac (Repentance)
-
Mods (0 • hidden)
- 21 Trinkets
- A Bushel of Burdens & Blessings
- Alphabirth+
- Anathema
- Andromeda
- Arachna
- Ascension
- Bael
- Balatro Jokers
- Baphomet
- Basement Moon
- Battle Fantasy
- Becky
- Bedroom Expanded
- Benevolence
- Benighted Soul
- Beyond
- Birthcake
- Birthcake: Rebaked
- Boss Butch!
- Brown Shapiro's Addons
- Chocolate Mod
- Community Remix
- Curiosity Crate
- D!Edith
- Damnation
- Dark Vaults
- David Pack
- Daydream all Day
- Doki Doki
- Eclipsed
- Edith: Rebuilt
- Elitium
- ENA Mod
- Ephemera
- Epiphany
- Fiend Folio
- Fiend Folio: RELOADED
- Foks' Booster Pack
- Fruity Rooms
- Furtherance
- Glacier's Laboratory
- Godmode Achieved
- Haemo's Gizmos
- Heaven's Call
- Hex Cards
- Insane Pain Mod
- Inscryption Card Pack
- Isaac's Limbus
- Job
- Joseph
- Juglans Box
- Kicks and Giggles
- Lazy MattPack
- Library Expanded
- Lost and Forgotten
- Magic Expanded
- Malware & Spam
- Martha of Bethany
- Mastema
- Me's Very Rocky Collection
- Minmaxers Anonymous
- Miscellany
- Mollith's Item Bunch
- More Penny Trinkets
- More Unus Cards
- Neapolitan Pack
- Noah
- Otherside Refractured
- Pail O Items
- Painted Paths
- PJJ & Niro's Collection
- Playable Machines
- Pop Pack
- Potato Packs
- Preyn's Collection
- Red Baby
- Repentance Negative
- Repentance Plus
- Reshaken
- Restored Mods
- Revelations
- Reverie
- Reverie: Make Good Omissions
- Road to Enlightenment
- Sacred Dreams
- Samael
- Sewing Machine
- Shattered Symbols
- Sweet Halloween
- TBOI Ascension
- TBoI: Regambled
- The Bimbing of AIsaac
- The binding of Neuro-sama
- The Forbidden Suits
- The Gauntlet
- The Miles Mod
- The Punished
- The Serpent
- The Sheriff
- The Sheriff: Most Wanted
- Virtue Items
- Warp Zone
27 more currently being worked on!
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| Name | Character | Starting items | Disabled rooms | Curse filters | Additional notes | End goal | Unlock condition | Reward |
|---|---|---|---|---|---|---|---|---|
| 1. [FF] The Devil's Harvest | Classic Fiend No HP. | - | - | - | - | Satan | - | - |
| 2. [FF] No Offense | Isaac No HP. | - | - | - | - | Isaac | - | - |
| 3. [FF] Handle With Care | China No HP. | - | - | - | - | Mom | - | Heartache, Cursed Urn, Shattered Cursed Urn |
| 4. [FF] Dad's Home+ | Isaac | XVII - The Stars
| - | - | Every encountered enemy and boss respawns in a random location in other rooms, even if they have been cleared.
This also includes other entities such as TNT and Shopkeepers. | Stage 2 | - | Green House |
| 5. [FF] Blursed | Isaac No HP. | - | - | - | Mom | - | - | |
| 6. [FF] Mr. Hands | Isaac No HP. | - | - | - | Mom's Heart | - | - | |
| 7. [FF] Frog Mode | Slippy | - | - | - | - | Mom's Heart | - | Slippy's Guts, Slippy's Heart, Golden Frog Head, Frog Puppet, Tattered Frog Puppet |
| 8. [FF] Dirty Bubble Challenge | Isaac | - | - | - | Every enemy projectile is replaced with a Bubble of a random size.
Some flaming or explosive projectiles are replaced with Explosive Bubbles. Homing projectiles are replaced with Fly Bubbles. | Mom's Heart | - | Petrified Gel |
| 9. [FF] Pen Island | Isaac No HP. | Planet X (x3)
Tiny Planet WNIC Devil's Umbrella Chewed Pen | - | - | Mom | - | - | |
| 10. [FF] The Real Jon | Isaac | - | - | - | A unique Elite Jon enemy constantly follows Isaac throughout the run.
This enemy cannot be damaged or killed unless Chaos Card, Euthanasia, or similar effects are used, in which case it will reappear in the next room. | Mom's Heart | - | Spare Ribs |
| 11. [FF] Brick By Brick | Golem | Brick Rock
Brick Rock (2x; one is golden) | - | Brick Rocks re-appear on impact, and are slowly attracted to Golem.
The golden one attracts slower than the other one. | Mom | - | Brick Seperator | |
| 12. [FF] Tower Offense | Golem | Brown Nugget
Boom! 6 random Grimlin trinkets (4 smelter, 2 golden) | - | The 6 Grimlin trinkets are rerolled in every room.
Golem is unable to access the Subway. | Mom | - | Lawn Darts | |
| 13. [FF] Craig's Challenge | Isaac No HP. | - | - | - | - | Other | - | - |
| 14. [FF] Allow Enemy Replacements | Isaac No HP. | The Battery
Ghost Baby Chirumiru Snooze Button | - | - | - | Mom | - | - |
| 15. [FF] Embryos Akimbo |  LilithNo HP. | BFFS!
Birthright How to Roll Lil Friend (x2) | - | - | Mom's Heart | - | - | |
| 16. [FF] Magna Farta | Tainted ??? No HP. | Rainbow Bean
| - | - | - | ??? | - | - |
| 17. [FF] Isaac Rebuilt |  Tainted Magdalene | The Belt
Birthright 4.5 Volt Sanguine Hook | - | Killing enemies with Sanguine Hook makes them drop  Half Hearts which disappear after a short while. | Mom | - | Deimos | |
| 18. [FF] Boss Makes a Dollar | Keeper No HP. | Treasure Map
The Compass Blue Map Cursed Penny | - | - | Mom | - | - | |
| 19. [FF] Baby Sensory | Image No HP. | - | - | - | Mom's Heart | - | - | |
| 20. [FF] The Gauntlet | Isaac | - | - | - | Isaac starts with 3¢ and no bombs.
The challenge takes place in a single custom-made stage whose goal is to defeat every single boss and mini-boss added in Fiend Folio, with the exception of Hermit. The challenge consists of multiple sections with a unique boss, each featuring a hub area that offers items and consumables for purchase. Stage paths are blocked with Colored Locks, the only way to unlock them being by defeating bosses, which each drop a Colored Puzzle Key corresponding to these locks, in addition to 7  Pennies.
Entering a section causes the previous section's door to be permanently sealed. | Gravedigger | - | Community Achievement Lost Artifact Atlas' Burden Pocket Rock-it Wormhole Rock Ridiculous Metal |
| 21. [FF] Imperishable Night | Inaba No HP. | BFFS!
Dichromatic Butterfly Sertraline Pack Key Piece 1 Key Piece 2 | - | - | Mega Satan | - | - | |
| 22. [FFBonus!] Hands On | Isaac No HP. | Transcendence
Pointy Rib | - | - | Mom | - | - | |
| 23. [FFBonus!] Punkychunk Challenge | Isaac No HP. | - | - | - | Mom | - | - | |
| 24. [FFBonus!] Follow the Rabbit | Isaac No HP. | - | - | - | - | Delirium | - | - |