The Sheriff: Most Wanted
| Name | Character | Starting items | Disabled rooms | Curse filters | Additional notes | End goal | Unlock condition | Reward |
|---|---|---|---|---|---|---|---|---|
| 1. [The Sheriff] Gold Rush | Tainted SheriffNo HP. | Bandit's Bandana
Midas' Touch Gold Dust | - | +15¢. Tainted Sheriff's ammo is determined the coin count. Instead of ammo pickups, enemies marked by Holster drop Gold Nugget that give +0.3 coins. | Mom's Heart | Unlock Tainted Sheriff, Bandit's Bandana, and Gold Dust. | Carriage Wheel | |
| 2. [The Sheriff] Wanted: Dead or Alive | The SheriffNo HP. | - | - | - | +2 damage. The Sheriff has a rifle instead of a revolver. The rifle shoots tracers which pierce through enemies. Quick Draw will instead create a large tracer which ricochets off of walls. The Sheriff starts with 30 max ammo and can no longer reload. Successfully hitting a shot will conserve the ammo. After killing the boss of every floor, The Bandit will appear, shooting The Sheriff and causing them to lose 5 ammo. At the end of the Mom boss fight, The Bandit will have run out of ammo himself, which is when The Sheriff can kill him. If The Sheriff also has no ammo, The Bandit can be punched by being ran in to. Different ammo packs can be purchased in shops which vary in price and ammo value. There will always be at least one Ammo (Medium) in every shop. | Mom | Beat a run as The Sheriff | Strange Sprout |
| 3. [The Sheriff] Sharpshooting | The SheriffNo HP. | - | - | - | Starts with 75 coins.
Starts in a room resembling the shooting range with no doors. The Sheriff must complete 10 shooting range minigames without losing all of their money to win. If The Sheriff runs out of money, the run is lost. The final shooting range layout is the same layout every time, and is a 2x2 room. | Win in the shooting range 10 times. | Unlock Rancher. | Shiny Emerald |