Challenges

Challenges are special runs in The Binding of Isaac which consist of specific items, set conditions, and an end goal.

The following challenges are available in Damnation. Click on a challenge to view additional details about it.

Name Character Starting items Disabled rooms Curse filters Additional notes End goal Unlock condition Reward
1. [DAMN] Sacrificial Ceremony Judas Birthright
God's Indiscriminate Wrath (consumable slot)		 - God's Indiscriminate Wrath can be used for infinite times. The LambUnlock Stary's Head. Murder Diary
2. [DAMN] Cry Your Own Epitaph Rainy Doll

No HP.		---- ???Unlock The Polaroid. The Rainy Doll
3. [DAMN] The Watcher Judas Schoolbag
How to Jump
Blasphemy (passive)		 -- Mom's HeartUnlock Judas. Blasphemy
4. [DAMN] American PokeGo Isaac Dr. Fetus
Poke Go
-Enemies die from explosion will revive and becomes friendly enemy. When Isaac has more than 6 friendly enemies, immediately kills them and spawns a random trinket. MomUnlock Dr. Fetus Slaver's Whip
5. [DAMN] Exam Oriented Education Isaac The D6
--If Isaac did not take penalty damage for the entire floor, spawns a golden Perfection upon clearing the boss room.
If Isaac tries to collide Trophy with less than 90 luck, remove all items Isaac has, and teleport Isaac to the boss rush (to get rid of Internet Addiction). Under this circumstance, every wave clear without taking damage offers 2 Perfection, clearing all waves spawns a Trophy.		 The LambUnlock The Negative.Juzzle (WIP)