Challenges
| Name | Character | Starting items | Disabled rooms | Curse filters | Additional notes | End goal | Unlock condition | Reward |
|---|---|---|---|---|---|---|---|---|
| 1. [DAMN] Sacrificial Ceremony | Judas | Birthright
God's Indiscriminate Wrath (consumable slot) | God's Indiscriminate Wrath can be used for infinite times. | The Lamb | Unlock Stary's Head. | Murder Diary | ||
| 2. [DAMN] Cry Your Own Epitaph |  Rainy DollNo HP. | - | - | - | - | ??? | Unlock The Polaroid. | The Rainy Doll |
| 3. [DAMN] The Watcher | Judas | Schoolbag
How to Jump Blasphemy (passive) | - | - | Mom's Heart | Unlock Judas. | - | |
| 4. [DAMN] American PokeGo | Isaac | Dr. Fetus
Poke Go | - | Enemies die from explosion will revive and becomes friendly enemy. When Isaac has more than 6 friendly enemies, immediately kills them and spawns a random trinket. | Mom | Unlock Dr. Fetus | - |