Challenges
| Name | Character | Starting items | Disabled rooms | Curse filters | Additional notes | End goal | Unlock condition | Reward |
|---|---|---|---|---|---|---|---|---|
| 1. [ddad]Don't Hurt Your Leg | Cain | Joint Effusion (x4)
Wooden Spoon | - | Items will disappear after 10s. Items in the boss room cycles between the original item and Blood Bag. Items outside of boss room cycles between the original item and Joint Effusion | Mom | - | - | |
| 2. [ddad]Curse of the Skull | The Forgotten | Brother Bobby
Sister Maggy Mongo Baby Compound Fracture Pointy Rib Brittle Bones Bone Spurs | - | Familiar's tears can deal damage to The Forgotten. When a familiar deals damage to The Forgotten, he will be transform into Dry Baby for one room. | Mom | - | - | |
| 3. [ddad]Out of Control | Lazarus | Non-responsible Aggregates
Chaos | - | Isaac can no longer vote for any proposal, and vote beggars will not appear. Item has a chance to become blind items. Spawns Forget Me Now every floor. Upon leaving the starting room, remove Forget Me Now. | Satan | - | - | |
| 4. [ddad]Money!!! | Judas | Money = Power
Restock Pay To Play Deep Pockets Money Worship Fanclub Lights Work for Nothing Key Piece 1 Key Piece 2 | - | - | All hearts, bombs, keys, consumables, batteries and trinkets turn into coins. Upon entering next floor, remove half of Judas' coins, and spawns Work for Nothing if Judas do not have one. | The Lamb | - | - |
| 5. [ddad]Alcoholic fiend | Judas No HP. | Cocktail Shaker
Deep Pockets | - | - | The Lamb | - | - | |
| 6. [ddad]Basement #8 | ??? No HP. | - | - | - | Other | - | - | |
| 7. [ddad]Vocabulary Test | Isaac No HP. | Isaac's Alphabet
Analog Stick | - | - | Isaac | - | - | |
| 8. [ddad]Sniper Duel | Isaac No HP. | Marked
Anima Sola | - | - | - | Mom | - | - |
| 9. [ddad]Soul Painter | The Lost No HP. | Transcendental Stroke
| - | - | - | ??? | - | - |