Challenges

Name	Character	Starting items	Disabled rooms	Curse filters	Additional notes	End goal	Unlock condition	Reward
1. [AB+] $#!7tiest day ever!	???	The Poop Brother Bobby Habit 9 Volt The Battery Brown Eye	-	-	Isaac is blindfolded and must use Brown Eye poops as his main source of damage.	Mom	Unlock ???.	Brown Eye
2. [AB+] Exploding Head Syndrome!	Magdalene	Pseudobulbar Affect Ipecac Continuum Spoon Bender	-	-	Isaac is blindfolded and only shoots transcendent ipecac tears in the direction he moves.	Mom	Unlock Magdalene.	Glitched Pickups
3. [AB+] Faust	Isaac	Goat Head Chaos Emperor's Crown		-	Isaac starts with 12 heart containers; at the start of every floor, he is automatically teleported to the boss room. He must use the chaos-mixed "Deals with the Devil" wisely as he has no access to treasure rooms.	Isaac	-	Emperor's Crown
4. [AB+] The Collector	Cain	Cauldron Hoarder Money = Power	-	-	Isaac must choose between using pickups traditionally, hoarding them as a way to get extra stat-ups from Hoarder and Money = Power, or absorbing them with Cauldron to gain extra items.	Mom's Heart	Unlock Cain.	Gebo
5. [AB+] Restless Leg Syndrome!	Isaac	Hot Coals	-	-	Bombs spawn at Isaac's feet if he stands still for longer than 2 seconds. The damage boost from Hot Coals further encourages continual movement.	Mom's Heart	-	Sowilo
6. [AB+] For the hoard!	Isaac	Hoarder Bum Friend Key Bum	-	-	Use your bums and stat upgrades from Hoarder to hoard every pickup throughout the run.	Satan	-	Naudiz
7. [AB+] Empty	Tainted Apollyon	Wormhole Void Abyss	-	-	Only active items spawn, use Void, Wormhole and Abyss to complete the challenge.	Mom	Unlock Tainted Apollyon.	Fehu