Challenges
Base game
- Isaac (Repentance+)
- Isaac (Repentance)
-
Mods (0 • hidden)
- 21 Trinkets
- A Bushel of Burdens & Blessings
- Alphabirth+
- Anathema
- Andromeda
- Arachna
- Ascension
- Bael
- Balatro Jokers
- Baphomet
- Basement Moon
- Battle Fantasy
- Becky
- Bedroom Expanded
- Benevolence
- Benighted Soul
- Beyond
- Birthcake
- Birthcake: Rebaked
- Boss Butch!
- Brown Shapiro's Addons
- Chocolate Mod
- Community Remix
- Curiosity Crate
- D!Edith
- Damnation
- Dark Vaults
- David Pack
- Daydream all Day
- Doki Doki
- Eclipsed
- Elitium
- ENA Mod
- Ephemera
- Epiphany
- Fiend Folio
- Foks' Booster Pack
- Fruity Rooms
- Furtherance
- Glacier's Laboratory
- Godmode Achieved
- Heaven's Call
- Hex Cards
- Insane Pain Mod
- Inscryption Card Pack
- Job
- Joseph
- Juglans Box
- Kicks and Giggles
- Lazy MattPack
- Library Expanded
- Lost and Forgotten
- Magic Expanded
- Malware & Spam
- Martha of Bethany
- Mastema
- Me's Very Rocky Collection
- Minmaxers Anonymous
- More Penny Trinkets
- More Unus Cards
- Neapolitan Pack
- Pail O Items
- Painted Paths
- PJJ & Niro's Collection
- Pop Pack
- Potato Packs
- Preyn's Collection
- Red Baby
- Repentance Negative
- Repentance Plus
- Reshaken
- Restored Mods
- Revelations
- Reverie
- Reverie: Make Good Omissions
- Road to Enlightenment
- Sacred Dreams
- Samael
- Sewing Machine
- Shattered Symbols
- Sweet Halloween
- TBOI Ascension
- TBOI Otherside
- TBoI: Regambled
- The Bimbing of AIsaac
- The binding of Neuro-sama
- The Forbidden Suits
- The Gauntlet
- The Miles Mod
- The Punished
- The Serpent
- The Sheriff
- Virtue Items
- Warp Zone
28 more currently being worked on!
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| Name | Character | Starting items | Disabled rooms | Curse filters | Additional notes | End goal | Unlock condition | Reward |
|---|---|---|---|---|---|---|---|---|
| 1. $#!7tiest day ever! | ??? No HP. | The Poop
Brother Bobby Habit 9 Volt The Battery Brown Eye | - | - | Isaac is blindfolded and must use Brown Eye poops as his main source of damage. | Mom | - | Brown Eye |
| 2. Exploding Head Syndrome! |  Magdalene No HP. | Pseudobulbar Affect
Ipecac Continuum Spoon Bender | - | - | Isaac is blindfolded and only shoots transcendent ipecac tears in the direction he moves. | Mom | - | Glitched Pickups |
| 3. Faust | Isaac No HP. | Goat Head
Chaos Emperor's Crown | - | Isaac starts with 12 heart containers; at the start of every floor, he is automatically teleported to the boss room. He must use the chaos-mixed "Deals with the Devil" wisely as he has no access to treasure rooms. | Isaac | - | Emperor's Crown |