[AB+] Exploding Head Syndrome! is an unlockable challenge in Alphabirth+, a mod for The Binding of Isaac.

Pseudobulbar Affect
Ipecac
Continuum
Spoon Bender

Note: this list does not include characters' default starting items.

Isaac is blindfolded and only shoots transcendent ipecac tears in the direction he moves.

The following is unlocked for completing the [AB+] Exploding Head Syndrome! challenge: Glitched Pickups

Unlock Magdalene.

• Download Alphabirth+ from the Steam Workshop.