Ipecac is an unlockable passive item in The Binding of Isaac.

+40 flat damage.
×0.33 fire rate multiplier.
×0.8 range multiplier.
×0.8 shot speed multiplier.
×0.4 tear size multiplier.

Isaac's tears become explosive and are fired in an arc.

Enemies within the blast radius become poisoned.

Damage multipliers do not affect Ipecac's flat damage bonus.

Ipecac shots deal half a heart of self-damage, and a full heart with 85 or a higher damage stat.

The poison deals damage equal to BaseDamage + 2, and ticks for a total of 2 times. The +40 flat damage does not apply to this formula.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Defeat Mom's Heart 6 times.

This item contributes towards the Bob transformation. Collecting 3 items from this set will grant Isaac poison immunity and make him leave green poisonous creep on the ground that deals 20 damage per second.

Ipecac can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Ipecac have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Ipecac

• Replaces tears with an arcing explosive poison shot
• Explosions can deal self damage
• Abyss: x1 explosive poison creep locust 2x Isaac's damage

• Check out the item description on the external Isaac Wiki.