Adrenaline is a passive item in The Binding of Isaac, added in the Afterbirth+ DLC.

Grants damage based on the number of Isaac's fully empty heart containers (half empty containers don't count).

Damage is calculated using the formula: ((2 × MissingHearts) ^ 1.6) × 0.1.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

This item contributes towards the Spun transformation. Collecting 3 items from this set will grant Isaac +2 damage, +0.15 speed and spawn a random pill.

Adrenaline can be found in the following item pools:

The following tags are applied to this item:

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Adrenaline

• Increases Isaac's damage for each empty red heart container he currently has
• Abyss: x1 locust .75x Isaac's damage

• Check out the item description on the external Isaac Wiki.