Genesis is an unlockable active item in The Binding of Isaac, added in the Repentance DLC.

Resets all of Isaac's stats and transformations, removes the floor's curses, and removes all of Isaac's items, except his starting ones and those with the quest tag, and teleports him to a special Bedroom.

The Bedroom contains a Bed, 2 random Chests, 2 Grab Bags, a random trinket, and a beam of light that can be used to exit the room and go down to the next floor.

For every item removed by Genesis, a set of 3 choice-pedestals will spawn in the room containing items from the same item pool as the removed item. Only one of these items can be taken. Each set appears one after the other.

If used on a final floor of the game, the beam of light will be replaced with a Crawl Space that leads back to the starting room of the floor.

Trinkets that were absorbed will simply be removed from Isaac's inventory with no extra item pedestals granted for them.

Picking up an active item from the choice of items will not drop it on the ground, but instead replace it with the new item.

Genesis affects all players in the run.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Defeat Ultra Greedier as Jacob and Esau.

Genesis can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Genesis have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Genesis

• Genesis is consumed to teleport Isaac to a special room
• All collected pedestal items are removed upon activation, and in the special room Isaac is given a choice between 3 items to replace each individual item that was removed
• This special room also contains 2 chests, 2 sacks, 1 random trinket, and a bed
• Abyss: x1 glitch locust 1x Isaac's damage
• Book of Virtues: x3 middle wisps - 2 hp - 3 damage
• Book of Virtues: All wisps are replaced by 3 normal wisps

• Check out the item description on the external Isaac Wiki.