Mega Mush is an unlockable active item in The Binding of Isaac, added in the Repentance DLC.

×4 damage multiplier.
+2 range.
-1.9 tears.

Turns Isaac into a invincible giant for 30 seconds, persisting between rooms and floors.

Isaac is able to destroy obstacles and doors by walking into them, as well as metal blocks. Cannot destroy doors that require a pickup in order to open.

Isaac deals massive amounts of rapid contact damage to enemies equal to 1 damage per tick (2400 per second).

Different types of weapons (e.g. Brimstone or Mom's Knife) are overwritten while the effect is active. Isaac is only able to shoot regular tears.

Prevents Isaac from using donation mechanics such as Blood Donation Machines or Devil Beggars, since they will get destroyed on contact.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Earn all Hard Mode completion marks for all non-tainted characters.

This item contributes towards the Fun Guy transformation. Collecting 3 items from this set will give Isaac +1 full red heart container.

Mega Mush can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Mega Mush have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Mega Mush

• Grow to a massive size for 30 seconds
• Isaac becomes invincible while active, dealing massive contact damage to enemies and crushing most obstacles and doors
• While active, tears gain 4x Isaac's damage and increased range but reduced fire rate
• Abyss: x1 giant stone locust 6x Isaac's damage
• Book of Virtues: x1 middle wisp - 2 hp - 3 damage

• Check out the item description on the external Isaac Wiki.