Soul of Jacob and Esau is an unlockable consumable in The Binding of Isaac, added in the Repentance DLC.

Spawns Esau as a temporary secondary character, that can be controlled by the same inputs as Isaac, and dies if his health runs out, or Isaac leaves the room.

Esau receives items equal to the number of items Isaac has, each based on the pool of the items Isaac's were obtained from.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this consumable for the previous Repentance version, check this page instead.

Defeat Hush and complete Boss Rush as Tainted Jacob.

The following special synergies and interactions for Soul of Jacob and Esau have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Soul of Jacob and Esau

• Spawns a friendly controllable Esau for the room with the same number of items as Isaac
• Clear Rune: Recharge 4

The following sounds are related to this consumable.

• Check out the consumable description on the external Isaac Wiki.