Karma is an unlockable trinket in The Binding of Isaac, added in the Afterbirth DLC.

Reduces the chances of the Donation Machine jamming.

Donating to a Donation Machine has a 33% chance to do one of the following:
• 40% → return 1¢ to Isaac's inventory
• 40% → heal Isaac for a full Red Heart
• 15% → grant +1 luck
• 5% → spawn a Beggar.

Donating to a Beggar has a chance to do one of the following:
• Refund 1¢ directly to Isaac.
• Heal a full Red Heart.
• Grant +1 luck.

Donating to a Blood Donation Machine or Confessional has a chance to do one of the following:
• Heal a full Red Heart.
• Spawn a Beggar.
• Grant +1 luck.

Donating to a Shop Restock Machine has a chance to grant +1 luck.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this trinket for the previous Repentance version, check this page instead.

Defeat The Lamb as Keeper.

The following tags are applied to this trinket:

The following special synergies and interactions for Karma have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Karma

• Reduces chance of the donation machine jamming
• Chance to gain +1 luck, heal 1 red heart, spawn a beggar, or refund a coin when donating
• Golden Trinket (without Mom's Box): Chance to gain +2 luck, heal 1 red heart, spawn a beggar, or refund a coin when donating
• Mom's Box: Chance to gain +2 luck, heal 1 red heart, spawn a beggar, or refund a coin when donating
• Mom's Box + Golden Trinket: Chance to gain +3 luck, heal 1 red heart, spawn a beggar, or refund a coin when donating

• Check out the trinket description on the external Isaac Wiki.