Pandora's Box - The Binding of Isaac

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Pandora's Box is an unlockable active item in The Binding of Isaac.

Spawns specific pickups or items depending on the floor it was used on:

Floor	Reward
Basement I	2 Soul Hearts
Basement II	2 Bombs and 2 Keys
Caves I	1 Boss item
Caves II	1 Boss item and 2 Soul Hearts
Depths I	4 Soul Hearts
Depths II	20 Pennies
Womb I	2 Boss items
Womb II	The Bible
??? (Blue Womb)	nothing
Sheol	1 Devil Room item and 1 Black Heart
Cathedral	1 Angel Room item and 1 Eternal Heart
Dark Room	nothing; unlocks Moving Box
Chest	1 Penny
The Void	nothing
Home	Red Key
The Shop / Ultra Greed	1 Penny

Alternate variants of the floor spawn the same pickups as the main floor they're based on (e.g. Dross = Basement).

For Greed Mode, it will always generate its second floor drops for each chapter that is before the Shop.

With Curse of the Labyrinth!, the floor is treated as the first floor of a chapter.

If used while Strange Key is held, the above pickup table is ignored, and it will instead spawn 6 higher quality items from a set of item pools, consuming both items in the process.

This page shows information as of the latest Repentance release.
To see latest up-to date information about this item for the new Repentance+ (Online Co-op) DLC, check this page instead.

Defeat The Lamb as Lazarus.

Pandora's Box can be found in the following item pools:

Name	Weight
Shop	1.0/1.0
Red Chest	1.0/1.0
Greed Shop	1.0/1.0

The following tags are applied to this item:

Id	Description
offensive	Can appear for Tainted Lost.

The following special synergies and interactions for Pandora's Box have been documented.

Mod	Item	Synergy
---	Book of Virtues	Spawns multiple regular wisps based on the current floor - 1. This means that no wisps will be spawned on the first floor.
---	The Book of Belial combined with Judas' Birthright	In addition to the regular payout, also spawns one of the following familiars: Blood Puppy, Dark Bum, Demon Baby, Incubus, Lil Abaddon, Lil Brimstone, Succubus, or Twisted Pair.