BRAINS! is an unlockable challenge in The Binding of Isaac, added in the Afterbirth DLC.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this challenge for the previous Repentance version, check this page instead.

Bob's Brain (x3)
Thunder Thighs

Note: this list does not include characters' default starting items.

There are no additional notes, rules, or conditions defined for this challenge.

Based on the rules set in the .xml file, the following special rooms are disabled during this challenge:

The following is unlocked for completing the BRAINS! challenge: Stud Finder

Defeat Isaac 5 times.

• Check out the challenge description on the external Isaac Wiki.