Isaac's Awakening is an unlockable challenge in The Binding of Isaac, added in the Repentance DLC.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this challenge for the previous Repentance version, check this page instead.

Spirit Sword
Mom's Bracelet
Trinity Shield

Note: this list does not include characters' default starting items.

There are no additional notes, rules, or conditions defined for this challenge.

Based on the rules set in the .xml file, the following special rooms are disabled during this challenge:

The following is unlocked for completing the Isaac's Awakening challenge: Spirit Sword

Defeat Mother for the first time.

• Check out the challenge description on the external Isaac Wiki.