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Rune Bag item
Rune Bag is an unlockable familiar in The Binding of Isaac, added in the Afterbirth DLC.
Description
Spawns a familiar that follows Isaac and drops a random rune or soul stone after clearing 7 or 8 rooms (alternating).
Note
This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.
How to unlock?
Defeat Isaac as 
Lilith.
Item pools
Rune Bag can be found in the following item pools:
| Name | Weight |
|---|---|
| Treasure Room |
1.0/1.0
|
| Secret Room |
1.0/1.0
|
| Greed Treasure Room |
1.0/1.0
|
| Greed Secret Room |
1.0/1.0
|
Tags
The following tags are applied to this item:
| Id | Description |
|---|---|
| summonable | Can be summoned via  Lemegeton. |
| offensive | Can appear for  Tainted Lost. |
| nocantrip | Not available as card effects during the Cantripped! challenge. |
Special synergies
The following special synergies and interactions for Rune Bag have been documented.
| Mod | Item | Synergy |
|---|---|---|
| --- | BFFS! | Drops a rune every 6 rooms. |
* Note that not all possible synergies and interactions are listed here.
Internal item description
Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.
Rune Bag
• Familiar that drops a random rune pickup every 7-8 rooms
• Abyss: x1 locust 1.5x Isaac's damage
External links
- Check out the item description on the external Isaac Wiki.
D12 
Censer 
Key Bum 
Seraphim 
Betrayal 
Zodiac