Blood Puppy - The Binding of Isaac

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Blood Puppy is an unlockable familiar in The Binding of Isaac, added in the Repentance DLC.

Spawns a familiar that chases nearby enemies, dealing 2 damage per tick (8.57 per second)

The familiar will evolve 2 times after killing some enemies.

Each boss killed by Blood Puppy counts as killing 4 non-boss enemies.

After killing 15 enemies Blood Puppy deals 7.5 damage per tick (16.07 per second) to enemies.

It will charge at enemies that are aligned with it in the cardinal directions, dealing 90 damage per second while charging.

Drops a Half Red Heart for every 10 enemies it kills.

Becomes hostile and will charge at Isaac if aligned with him, dealing half a heart of damage.

Can be damaged by Isaac to return it back to normal after it takes enough damage. It has 20 health points + 90 armor.

After killing 25 more enemies (40 total) Increases in size and deals 15 damage per tick (150 per second).

Destroys obstacles it runs into while charging.

Deals a full heart of damage to Isaac.

Drops a full Red Heart after every 10 kills.

Has 50 health points + 90 armor.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Defeat Mother as Lilith.

Blood Puppy can be found in the following item pools:

Name	Weight
Treasure Room	1.0/1.0
Red Chest	0.5/1.0
Curse Room	1.0/1.0
Greed Treasure Room	1.0/1.0
Greed Curse Room	1.0/1.0
Ultra Secret Room	1.0/1.0
Baby Shop	1.0/1.0

The following tags are applied to this item:

Id	Description
summonable	Can be summoned via Lemegeton.
monstermanual	Can be summoned via Monster Manual.
offensive	Can appear for Tainted Lost.

The following special synergies and interactions for Blood Puppy have been documented.

Mod	Item	Synergy
---	BFFS!	×2 damage only for the first phase.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Blood Puppy

• Familiar that chases enemies and deals contact damage
• Evolves to more aggressive forms with higher damage and new abilities upon killing a certain number of enemies
• Can attack and deal damage to Isaac in its evolved forms
• Damaging it can return it to its normal state
• Abyss: x1 locust .75x Isaac's damage