Meat Cleaver is an unlockable active item in The Binding of Isaac, added in the Repentance DLC.

Splits each enemy into two smaller versions that have ~40% health each.

Normal enemies can be split up to 2 times, while champions and bosses up to 3 times. Attempting to split over the maximum allowed amount deals 25 damage to enemies instead.

Some enemies, such as Mr. Maw that has a cable holding the two parts, will be detached instead.

Cannot split invincible enemies, including Hosts while lowered.

Final bosses cannot be split.

Delirium has no limit on how many times it can split.

Some bosses have special behavior when split:
• Gemini will separate both of its pieces.
• Loki turns into Lokii.
• Chub / C.H.A.D. / Carrion Queen will instantly die.
• Gabriel / Uriel will make each copy spawn a Key Piece.
• Horny Boys will turn into Loki and Hornfel.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Defeat Mother as Isaac.

Meat Cleaver can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Meat Cleaver have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Meat Cleaver

• Split all enemies in the room into 2 smaller copies with 40% of the original's health
• Abyss: x2 small locusts .5x Isaac's damage
• Book of Virtues: x1 middle wisp - 2 hp - 3 damage
• Book of Virtues: All wisps are split in 2 and deal half damage

• Check out the item description on the external Isaac Wiki.