Soul of Lilith is an unlockable consumable in The Binding of Isaac, added in the Repentance DLC.

Grants a permanent passive item familiar from the Baby Shop item pool.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this consumable for the previous Repentance version, check this page instead.

Defeat Hush and complete Boss Rush as Tainted Lilith.

The following special synergies and interactions for Soul of Lilith have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Soul of Lilith

• Grants a permanent familiar
• Clear Rune: Recharge 12

The following sounds are related to this consumable.

• Check out the consumable description on the external Isaac Wiki.