Soul of the Lost is an unlockable consumable in The Binding of Isaac, added in the Repentance DLC.

Isaac dies and visually turns into The Lost, with all of his benefits and weaknesses, until leaving the room.

This allows Isaac to take a Devil Deal for free, take one free hit due to the Holy Mantle, and enter the Mausoleum / Gehenna door for free.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this consumable for the previous Repentance version, check this page instead.

Defeat Hush and complete Boss Rush as Tainted Lost.

The following special synergies and interactions for Soul of the Lost have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Soul of the Lost

• Transforms Isaac into the Lost for the room
• Clear Rune: Recharge 3

The following sounds are related to this consumable.

• Check out the consumable description on the external Isaac Wiki.