Boss Rush is a room in The Binding of Isaac.

The Boss Rush room becomes available upon defeating Mom in Chapter 3 within 20 minutes, or within 25 minutes during the alternate path. The entrance appears in Mom's Boss Room.

Boss Rush is a large room which contains 2, 4, or 8 random items from the Treasure Room item pool.

Upon picking up one of the items, the other disappear, and waves of 15 bosses will start to appear.

Each wave consists of 2 random bosses, and the next wave will not start until the previous one has been cleared.

Each boss may only appear once.

The following bosses may not appear in Boss Rush:
• Scolex.
• Conquest.
• Lokii.
• Teratoma.
• Daddy Long Legs.
• Triachnid.
• Mama Gurdy.
• Mr. Fred.
• Any final boss.
• Any Sin or Super Sin.
• Krampus.
• Uriel or Gabriel.
• Any boss added in Afterbirth+ or Repentance.

Completing Boss Rush will award an additional item from the Treasure Room item pool.

The Boss Rush door remains open as long as 20 minutes have not passed. This is also the case upon completing Boss Rush.

If the fight has been exited prior to completion, it can be restarted only by picking up an item pedestal inside the room, opening any chest, or picking up a Grab Bag.

The 20-minute timer can be bypassed by using Mama Mega! or Mega Bean inside the Boss Room, or by holding Broken Shovel.

Boss Rush may not be entered if Mom has been defeated for the first time on a save file.

This page shows information as of the latest Repentance release.
To see latest up-to date information about this room for the new Repentance+ (Online Co-op) DLC, check this page instead.

The Boss Rush is associated with the Treasure Room item pool. Items that spawn in this room will be selected from the associated item pool.

• Check out the room description on the external Isaac Wiki.