Onan's Streak is an unlockable challenge in The Binding of Isaac, added in the Afterbirth DLC.
This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this challenge for the previous Repentance version, check this page instead.
Note: this list does not include characters' default starting items.
+2 damage.
Missing a shot deals half a heart of damage to Judas.
The following is unlocked for completing the Onan's Streak challenge: Kidney Stone
Unlock Judas and It Lives!