Isaac's Heart - The Binding of Isaac

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Isaac's Heart is an unlockable familiar in The Binding of Isaac.

Spawns a heart familiar that follows Isaac and tries to position itself in the opposite direction of Isaac's shooting.

Isaac takes damage if the heart is hurt, but Isaac's body becomes immune to damage, excluding interactable objects such as Blood Donation Machines and Devil Beggars.

The heart charges up as Isaac fires. At full charge, upon releasing the fire button, it will knock back nearby enemies and tears, create a small puddle of red creep, and release blood shots in 8 directions that deal 8 damage.

Makes Isaac's body deal contact damage equal to 2x Isaac's damage stat per tick (4x per second).

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Defeat Isaac as The Lost

Isaac's Heart can be found in the following item pools:

Name	Weight
Treasure Room	1.0/1.0
Greed Treasure Room	1.0/1.0
Ultra Secret Room	1.0/1.0

The following tags are applied to this item:

Id	Description
uniquefamiliar	Cannot be duplicated via Box of Friends.
nolostbr	Unavailable for The Lost after obtaining Birthright.
summonable	Can be summoned via Lemegeton.

The following special synergies and interactions for Isaac's Heart have been documented.

Mod	Item	Synergy
---	BFFS!	Fires additional shots in random directions, and leaves larger puddles of creep.
---	Abyss	Spawns a blue locust that has a chance to punch enemies back.