Isaac's Heart is an unlockable familiar in The Binding of Isaac.

Spawns a heart familiar that follows Isaac and tries to position itself in the opposite direction of Isaac's shooting.

Isaac takes damage if the heart is hurt, but Isaac's body becomes immune to damage, excluding interactable objects such as Blood Donation Machines and Devil Beggars.

The heart charges up as Isaac fires. At full charge, upon releasing the fire button, it will knock back nearby enemies and tears, create a small puddle of red creep, and release blood shots in 8 directions that deal 8 damage.

Makes Isaac's body deal contact damage equal to 2x Isaac's damage stat per tick (4x per second).

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Defeat Isaac as The Lost

Isaac's Heart can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Isaac's Heart have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Isaac's Heart

• Following familiar that charges and fires rings of tears
• Upon collecting this familiar, Isaac becomes immune to damage and the heart takes damage instead
• Abyss: x1 knockback locust .5x Isaac's damage

• Check out the item description on the external Isaac Wiki.