Giant Cell is a passive item in The Binding of Isaac, added in the Repentance DLC.

Taking damage summons a miniature Isaac familiar known as Minisaac, that chases enemies and fires tears on its own.

Minisaacs' tear damage is based on the formula: 1.20 + 0.15 × CurrentFloor.

The familiar shoots 3 times per second.

Minisaacs persist between rooms and floors.

Each Minisaac starts with 15 health points that are constantly drained with a rate of 0.4 per second, until it reaches 0.8 HP.

Whenever Isaac takes damage, all Minisaacs are healed back to their full health.

Minisaacs take damage from enemy projectiles and contact damage. They can also be damaged by Isaac's bombs.

Minisaacs are immune to spikes and lasers.

No more than 16 Minisaacs can exist at a time.

When playing as The Forgotten, a special Minisaac variant will spawn that inherits the bone club attack. This familiar deals 8.1 + 0.9 × CurrentFloor damage, and swings its bone club 1.5 times per second.

Minisaacs receive wings if Isaac has any form of flight.

Has a 1% chance of being dropped upon defeating Polycephalus.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Giant Cell can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Giant Cell have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Giant Cell

• Taking damage spawns a mini familiar that chases and attacks enemies
• These mini familiars last until destroyed from taking enough damage. Max of 16 at a time
• Abyss: x1 locust .75x Isaac's damage

• Check out the item description on the external Isaac Wiki.