Tooth and Nail is a passive item in The Binding of Isaac, added in the Repentance DLC.

Causes Isaac to turn to stone and sprout spikes every 6 seconds. Isaac is immune to damage while in this state, and deals 40 damage per tick (80 per second). The effect lasts for 1 second.

Isaac will flash white 4 times before turning into stone on the 4th flash. These flashes are accompanied with a ticking sound.

Can be used to enter Curse Rooms and open Spiked Chests for free, but cannot be used to play Blood Donation Machines and Devil Beggars for free.

Has a 1% chance of being dropped upon defeating Tuff Twins.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Tooth and Nail can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Tooth and Nail have been documented.

* Note that not all possible synergies and interactions are listed here.

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Tooth and Nail

• Every 6 seconds, transform into a spiky statue form for 1 second
• In this statue form Isaac is invincible to most forms of damage and deals 40 contact damage to enemies
• Abyss: x1 shield locust 1x Isaac's damage

• Check out the item description on the external Isaac Wiki.