Hypercoagulation is an unlockable passive item in The Binding of Isaac, added in the Repentance DLC.

Taking damage or donating health makes a red heart launch out of Isaac that disappears after 1.5 seconds.

The heart depends on the amount of health spent: half heart spent will produce half a heart, while a full heart will produce a full heart.

Damage sources that scale up from half a heart to a full heart, starting from Chapter 4, will still only produce half a heart.

No hearts are spawned when spending heart containers in Devil Deals.

This page shows the latest information as of the new Repentance+ (Online Co-op) DLC.
To see information about this item for the previous Repentance version, check this page instead.

Defeat Delirium as Tainted Magdalene.

Hypercoagulation can be found in the following item pools:

The following tags are applied to this item:

Below is the Internal Item Description as shown in-game.
Note that some stat changes are not displayed here. Please see the main description for the full effects.

Hypercoagulation

• When damaged, the health just lost spawns as a heart pickup sliding across the floor
• Hearts spawned by this effect disappear after 2 seconds if not collected
• Abyss: x1 locust 1x Isaac's damage

• Check out the item description on the external Isaac Wiki.