Insane Mode - The Binding of Isaac

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Insane Mode is an unlockable difficulty in Community Remix, a mod for The Binding of Isaac.

This is a gamemode that can be selected on the character menu.

This mode come with significent nerfs such as:
• Isaac's heart cap is reduced to 6 hearts (or 3 if playing as The Forgotten).
• Heart drops as room clear rewards have a 66% chance to be replaced with nothing.
• Planetariums have a chance to be Hexed.
• Bomb pickups have a chance to be replaced with a Troll Bomb when touched.
• Pacers and Gushers leave red creep on the floor.
• Treasure Room on first floor now require a key to be opened.

Beating any final boss other than Mom on Insane Mode will reward Isaac with an Insane Pin, which will be displayed in the character menu on top of the post-it note for the character it has been beat with. It will also unlock that character's Insane mode unlock.

Beating Insane Mode for first time will also unlock Insane Pendant and Shrunken Head.

If Alt Character Unlock Methods option is enabled in mod's options, then beating Mega Satan in Insane Mode with unlock character's starting item / pickup such as Holy Mantle for The Lost Razor Blade for Eve, Full Health pill for Magdalene etc.

Defeat Mom's Heart 5 times.

The following special synergies and interactions for Insane Mode have been documented.

Mod	Item	Synergy
---	Isaac	Unlocks Akedah.
---	Magdalene	Unlocks Communion Wine.
---	Cain	Unlocks Lucky Charm.
---	Judas	Unlocks Ceremonial Blade.
---	???	Unlocks Bygone.
---	Eve	Unlocks Occam's Razor.
---	Samson	Unlocks Donkey's Jawbone.
---	Azazel	Unlocks Goat Heart.
---	Lazarus	Unlocks Misericorde.
---	Eden	Unlocks _NULL.
---	The Lost	Unlocks Sanctified Heart.
---	Lilith	Unlocks Dark Penny.
---	Keeper	Unlocks Bum Mug.
---	Apollyon	Unlocks Cloud Nine.
---	The Forgotten	Unlocks Hand-Me-Downs.
---	Bethany	Unlocks Beth's Virtue.
---	Jacob and Esau	Unlocks Twin Candles.
Community Remix	Adam	Unlocks Ophiuchus.
Community Remix	Abel	Unlocks Gacha Bombs.
Community Remix	Elijah	Unlocks Secret Tunnels.