Sacrificial Chalice is an unlockable familiar in Mastema, a mod for The Binding of Isaac.

Grants a chalice familiar that gets filled with blood each time Isaac gets hit.

Spawns devil-themed rewards on each floor based on the amount of hits taken on the previous floor.

Possible payouts • Black Hearts.
• Red Chests.
• Black Locusts.
• A random item from the Devil Room item pool.

If the chalice spawns an item, it will not spawn any of the other possible rewards.

Taking at least one hit per floor will ensure that the chalice will not activate negative effects.

Possible negative payouts • 1-3 broken hearts.
• / removing 2 hearts.

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Every 5 hits, the chalice will increase in level. Each level increases the amount of rewards spawned as well as the chance for an item. The level is reset on each new floor after it pays out:

• Level 1: One reward, 5-20% chance for an item.
• Level 2: Two rewards, 25-45% chance for an item.
• Level 3: Three rewards, 50-70% chance for an item.
• Level 4: Four rewards, 75-100% chance for an item.

Defeat Mother as Tainted Mastema.

Sacrificial Chalice can be found in the following item pools:

The following tags are applied to this item:

The following special synergies and interactions for Sacrificial Chalice have been documented.

* Note that not all possible synergies and interactions are listed here.

• Check out the item description on the mod's external Wiki.
• Download Mastema from the Steam Workshop.