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#91Soul of the Lost"Leave your body behind"Rune
Isaac dies and visually turns into The Lost, with all of his benefits and weaknesses, until leaving the room.

This allows Isaac to take a Devil Deal for free, take one free hit due to the Holy Mantle, and enter the Mausoleum / Gehenna door for free.
Unlock: Defeat Hush and complete Boss Rush as Tainted Lost.
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Unlockable Grants costume Has YouTube video Animated icon Favorite (?)