#297Pandora's Box"? ?"Active item (one time use)
Spawns specific pickups or items depending on the floor it was used on:

Floor Reward
Basement I 2 Soul Hearts
Basement II 2 Bombs and 2 Keys
Caves I 1 Boss item
Caves II 1 Boss item and 2 Soul Hearts
Depths I 4 Soul Hearts
Depths II 20 Pennies
Womb I 2 Boss items
Womb II The Bible
??? (Blue Womb) nothing
Sheol 1 Devil Room item and 1 Black Heart
Cathedral 1 Angel Room item and 1 Eternal Heart
Dark Room nothing; unlocks Moving Box
Chest 1 Penny
The Void nothing
Home Red Key
The Shop / Ultra Greed 1 Penny
Alternate variants of the floor spawn the same pickups as the main floor they're based on (e.g. Dross = Basement).

For Greed Mode, it will always generate its second floor drops for each chapter that is before the Shop.

With Curse of the Labyrinth!, the floor is treated as the first floor of a chapter.

If used while Strange Key is held, the above pickup table is ignored, and it will instead spawn 6 higher quality items from a set of item pools, consuming both items in the process.
Unlock: Defeat The Lamb as Lazarus.
- Tags -- Synergies - - Links -

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Added in DLC
Unlockable Grants costume Has YouTube video Animated icon Favorite (?)