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#297Pandora's Box"? ?"Active item (one time use)
Spawns specific pickups or items depending on the floor it was used on:

Floor Reward
Basement I 2 Soul Hearts
Basement II 2 Bombs and 2 Keys
Caves I 1 Boss item
Caves II 1 Boss item and 2 Soul Hearts
Depths I 4 Soul Hearts
Depths II 20 Pennies
Womb I 2 Boss items
Womb II The Bible
??? (Blue Womb) nothing
Sheol 1 Devil Room item and 1 Black Heart
Cathedral 1 Angel Room item and 1 Eternal Heart
Dark Room nothing; unlocks Moving Box
Chest 1 Penny
The Void nothing
Home Red Key
The Shop / Ultra Greed 1 Penny
Alternate variants of the floor spawn the same pickups as the main floor they're based on (e.g. Dross = Basement).

For Greed Mode, it will always generate its second floor drops for each chapter that is before the Shop.

With Curse of the Labyrinth, the floor is treated as the first floor of a chapter.

If used while Strange Key is held, the above pickup table is ignored, and it will instead spawn 6 higher quality items from a set of item pools, consuming both items in the process.

Unlock: Defeat The Lamb as Lazarus.

- Tags -- Synergies - - Links -

▾ITEMS ()▾

D infinity Dogma Jar of Wisps Flip Everything Jar



Heart Heart (half) Heart (soul) Heart (eternal) Heart (double) Black Heart Gold Heart Heart (half soul) Scared Heart Blended Heart Bone Heart Rotten Heart Penny Nickel Dime Double Penny Lucky Penny Sticky Nickel Golden Penny Key Golden Key Key Ring Charged Key Golden Bomb Golden Troll Bomb Giga Bomb Mega Chest Mom's Chest Mega Battery Golden Battery


Hagalaz Jera Ehwaz Dagaz Ansuz Perthro Berkano Algiz Golden Pill Golden Horse Pill


Slot Machine Blood Donation Machine Fortune Telling Machine Beggar Devil Beggar Shell Game Key Master Donation Machine Bomb Bum Shop Restock Machine Greed Donation Machine Mom's Dressing Table Battery Bum Hell Game Crane Game Confessional Rotten Beggar


Magdalene Samson Azazel Lilith Bethany Tainted Magdalene Tainted Eve Tainted Lilith Tainted Bethany


Fun Guy Conjoined Leviathan